| DESCRIPTION |
Metco® is an antimicrobial drugs with high activity against anaerobic bacteria and protozoa; indications include trichomonal vaginitis, bacterial vaginitis, and Entamoeba histolytica and Giardia lamblia infections. It is also used for surgical and gynaecological sepsis in which its activity against colonic anaerobes, especially Bacteroids fragilis, is important. Metronidazole is also effective in the treatment of antibiotic associated colitis (pseudomembranous colitis). Metco® is readily absorbed following administration by mouth and bioavailability approaches 100%. Metco® is widely distributed in the body. It appears in most body tissues and fluids. |
| INDICATIONS |
Anaerobic infections (including dental), protozoal infections, Helicobater pylori eradication and skin infections. |
| DOSAGES AND ADMINISTRATION |
By mouth.
Indications
|
Duration of
Dose |
Adult and
Child: above 10 years old |
Child |
| 7-10 years |
3-7 years |
1-3 years |
| Amoebiasis |
|
|
|
|
|
| a) Amoebic dysentery |
5-10 days or 2 days |
800 mg thrice daily or 2 gm once daily |
400 mg thrice daily |
200 mg four times daily |
200 mg thrice daily |
| b) Asymptomatic amoebic infection |
5-10 days |
400-800 mg thrice daily |
200-400 mg thrice daily |
100-200 mg four times daily |
100-200 mg thrice daily |
| c) Intestinal disease in less susceptible patients and chronic amoebic hepatitis |
5-10 days or 2 days |
400-800 mg thrice daily or 2 gm once daily |
200-400 mg thrice daily |
100-200 mg four times daily |
100-200 mg thrice daily |
| d) Extra -intestinal amoebiasis |
5-10 days |
400-800 mg thrice daily |
200-400 mg thrice daily |
100-200 mg four times daily |
100-200 mg thrice daily |
| e) Symptomless cyst passers |
5-10 days |
400-800 mg thrice daily |
200-400 mg thrice daily |
100-200 mg four times daily |
100-200 mg thrice daily |
| Giardiasis |
3 days |
2 gm once daily |
1 gm once daily |
700 mg once daily |
500 mg once daily |
| Urogenital trichomoniasis (where reinfection of adults is likely the partner should be treated concurrently) |
7 days or 2 days or 1 day |
200 mg thrice daily or at morning 800 mg, at night 1200 mg or 2 gm once daily |
100 mg thrice daily |
100 mg twice daily |
50 mg thrice daily |
| Bacterial vaginitis |
7 days or Single dose |
400 mg twice daily or 2 gm |
|
|
|
| Acute dental infections |
3-7 days |
400 mg thrice daily |
100 mg thrice daily |
100 mg twice daily |
50 mg thrice daily |
| Severe ulcerative gingivitis |
3 days |
400 mg thrice daily |
100 mg thrice daily |
100 mg twice daily |
50 mg thrice daily |
| Anaerobic infection |
7 days |
800 mg initially then 400 mg thrice daily |
7.5 mg/kg thrice daily in divided dose |
| Prevention of post operative infections due to anaerobic bacteria |
400 mg 8 hourly during 24 hours immediately preceding operation and then after operation 400 mg thrice daily for 7 days. |
7.5 mg/kg 8 hourly during 24 hours immediately preceding operation and then after operation 7.5 mg/kg thrice daily for 7 days. |
|
| CONTRAINDICATIONS |
Known hypersensitivity to metronidazole. |
| PRECAUTIONS |
Disulfiram-like reaction with alcohol, hepatic impairment and hepatic encephalopathy; clinical and laboratory monitoring advised if treatment exceeds 10 days. |
| PREGNANCY AND LACTATION |
There is inadequate evidence of the safety of metronidazole in pregnancy. Metco® should not, therefore, be given during pregnancy or during lactation unless the physician considers it essential; in these circumstances the short, high-dosage regimens are not recommended. |
| SIDE-EFFECTS |
Nausea, vomiting, unpleasant taste, furred tongue, and gastrointestinal disturbances; rashes, urticaria and angioedema; rarely drowsiness, headache, dizziness, ataxia, darkening of urine, and anaphylaxis; on prolonged or intensive therapy peripheral neuropathy, transient epileptiform seizures, and leucopenia. |
| PHARMACEUTICAL PRECAUTIONS |
Store in a cool and dry place, away from light. Keep out of reach of children. |
| PACKAGING |
Metco® tablet: Box containing 10 strips of 10 tablets each. Each tablet contains metronidazole BP equivalent to metronidazole 400 mg.
Metco® suspension: Bottle containing 60 ml suspension in amber glass bottle. Each 5 ml contains metronidazole BP equivalent to metronidazole 200 mg.
Suspension manufactured by:
ESKAYEF BANGLADESH LTD
GAZIPUR, BANGLADESH
® REGD.TRADEMARK |
Tablet manufactured by :
ESKAYEF BANGLADESH LTD
DHAKA, BANGLADESH
® REGD.TRADEMARK
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