Introduction
Sound health is vital to our meaningful and worthwhile existence. In finding sustainable solutions to healthcare challenges, Eskayef is committed to improve the healthcare environment in Bangladesh by providing access to safe, effective and affordable medicines and related healthcare services to the people who need them.
In order to prevent cross-contamination between products as well as to safeguard the workers' health and environmental safety, cephalosporin products must be manufactured in separate and dedicated self-contained areas with separate air handling facilities. True to its vision of offering world-class healthcare products, the new dedicated state-of-the-art cephalosporin plant has contructed under the exclusive technical supervision of one of the leading European pharmaceutical consultants.



This new facility is being designed to conform to international cGMP with particular emphasis on meeting standards of the UK.

Eskayef’s cephalosporin plant

Infrastructure
Building: 
» Basement : 10,500 sft (Store and Warehouse)
» Ground floor : 11,400 sft (Change Room, Utility unit, Garment
Washing Room, Material Receiving Unit, Training, Room, Library, Canteen etc)
» First floor : 11,400 sft (Production floor)
» Second floor : 11,400 sft (Utility Unit, Quality Control Unit and
Microbiological Laboratory Unit)

Manufacturing dosage forms
» Oral solid:
    Tablet (Coated & uncoated)
    Capsule

» Oral liquid:
    Powder for suspension

» Parenteral:
    Vial
    Ampoule

Salient features of manufacturing plant

The dedicated cephalosporin plant has designed from Elomatic life science. All kinds of designs specially manufacturing specification, utility and production floor are designed by Elomatic life science, a renowned engineering and technical consultation services in Finland.
Completely isolated from other facilities, independent facility.

HVAC (Heating, Ventilation & Air-Conditioning) system: Most upgraded world-class HVAC system is designed. Terminal HEPA (High Efficency Particulate Air) filters exist in all processessing areas.
The plant is completely auto-controlled by Central Building Management System (BMS) from Siemens.
Purified water, Water For Injection and Purified Steam system of European origin (Italy) are installed for cephalosporin products. Cold loop temperature is maintained <12°c.
The entire production unit floor is composed of Self Leveling EPOXY coating with anitmicrobial component.
Captive power generator is available to guarantee uninterrupted power supply to the plant. Gas power generator- 2.4 MW is available in this plant.

Manufacturing equipments
Sourcing of most of the equipments for the facility is made from Europe with provisions for proper validation and to guarantee consistent performance and reliability.
Vial lines including washing, sterilization, filling, labeling etc. complete operations are built up from European source (Italy). These systems also include auto weight control system.
Autoclave and machinaries of dry powder for suspensions are also from European source (Italy).

UPGRADED WORLD-CLASS STANDARD HVAC SYSTEM 

HVAC stands for "heating, ventilation and air-conditioning". The three functions of heating, ventilation and air-conditioning are closely interrelated. All seek to provide thermal comfort, acceptable indoor air quality, reasonable installation, operation and maintenance costs. HVAC systems can provide ventilation, reduce air infiltration and maintain pressure relationships between spaces.

Heating, ventilating and air-conditioning (HVAC) systems can play several roles to reduce the environmental impact of buildings. The primary function of HVAC systems is to provide healthy and comfortable interior conditions for occupants; well-designed, efficient systems do this with minimal non-renewable energy and air and water pollutant emissions. 

Heating: Heating systems may be classified as central or local. Central heating is often used in cold climates to heat private houses and public buildings. Such a system contains a boiler, furnace, or heat pump to heat water, steam, or air, all in a central location such as a furnace room in a home or a mechanical room in a large building. The system also contains piping or ductwork to distribute the heated fluid, and radiators to transfer this heat to the air. The radiators may be mounted on walls or buried in the floor to give under-floor heat.
In boiler fed or radiant heating systems, all but the simplest systems have a pump to circulate the water and ensure an equal supply of heat to all the radiators. The heated water can also be fed through another heat exchanger inside a storage cylinder to provide hot running water.

Ventilation: Ventilation is the process of "changing" or replacing of air in any space to remove moisture, odors, smoke, heat, dust and airborne bacteria. Ventilation includes both the exchange of air to the outside as well as circulation of air within the building. It is one of the most important factors for maintaining acceptable indoor air quality in buildings. 

Air-conditioning: An air conditioning system provides cooling, ventilation and humidity control for all or part of a house or building. The Freon or other refrigerant provides cooling through a process called the refrigeration cycle. The refrigeration cycle consists of four essential elements to create a cooling effect. A compressor provides compression for the system. This compression causes the cooling vapor to heat up. The compressed vapor is then cooled by heat exchange with the outside air, so that the vapor condenses to a fluid, in the condenser. The fluid is then pumped to the inside of the building, where it enters an evaporator. In this evaporator, small spray nozzles spray the cooling fluid into a chamber, where the pressure drops and the fluid evaporates. Since the evaporation absorbs heat form the surroundings, the surroundings cool off, and thus the evaporator absorbs or adds heat to the system. The vapor is then returned to the compressor. A metering device acts as a restriction in the system at the evaporator to ensure that the heat being absorbed by the system is absorbed at the proper rate.

Terminal HEPA (high efficiency particulate air) filters: HEPA filter is a type of high-efficiency air filter.
Function: HEPA filters can remove at least 99.97% of airborne particles 0.3 micrometres (µm) in diameter. Particles of this size are the most difficult to filter and are thus considered the most penetrating particle size (MPPS). Particles that are larger or smaller are filtered with even higher efficiency.

BUILDING MANAGEMENT SYSTEM (BMS)
Building Management System (BMS) is a high technology system installed on buildings that controls and monitors the building’s mechanical and electrical equipment such us air handling and cooling plant systems, lighting, power systems, fire systems, and security systemsbuilding technologies are a leading supplier of products, systems and services for security, safety, comfort, eco-efficiency and economy in buildings.

PURIFIED WATER, WATER FOR INJECTION & PURIFIED STEAM SYSTEM

Purified water, water for injection and purified steam system are constructed by Stilmas, an Italian company specialized in the research, development and construction of the most advanced water treatment, distillation and purification plants, as well as ultra pure steam production systems in accordance with the latest guidelines and regulations set by FDA, cGMP and International Pharmacopoeias.

Water for Injection

Water for injection Purified water generation unit Purified steam system

Cold loop temperature is maintained below 12°c, which ensures no microbiol growth.

SELF LEVELING EPOXY SURFACING

The production floor is made by self leveling EPOXY with anitmicrobial components in the entire process area. Self leveling epoxy (SLE) is a durable, cost-effective moderate duty floor surfacing that will provide a performance level in between a troweled surfacer and a protective coating. 

Application:
Suited for painting the floor require it is very clean, beautiful, no dust and no bacterium. Also especially suited for the area that requires abrasion resistance, pressure resistance, impact resistance and anticorrosion such as production area, laboratory, office etc.
Key features:
1. Dust proof, wet proof, abrasion resistant and chemicals resistant.
2. The surface is smooth and beautiful, easy to construct and maintain, with a little elasticity.
3. Good adhesion, resistant to compress and impact.
4. Thickness: 3 mm.

CAPTIVE POWER GENERATION UNIT
Captive power generator is available to guarantee uninterrupted power supply to the plant. Gas power generator- 2.4 MW is available in this plant.